Version 5.4
| Homo sapiens Protein: AFM | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-23841.5 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | AFM | ||||||||
| Protein Name | afamin | ||||||||
| Synonyms | ALB2; ALBA; ALF; | ||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000226355 | ||||||||
| InnateDB Gene | IDBG-23839 (AFM) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Vitamin E binding protein. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the regulation and transport of vitamin E at the blood-brain barrier. {ECO:0000269PubMed:12463752, ECO:0000269PubMed:15952736, ECO:0000269PubMed:19046407}. | ||||||||
| Subcellular Localization | Secreted. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | High level detected in plasma but also in extravascular fluids such as follicular and cerebrospinal fluids (at protein level). {ECO:0000269PubMed:15952736}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR000264
ALB/AFP/VDB IPR001703 Alpha-fetoprotein IPR014760 Serum albumin, N-terminal IPR020858 Serum albumin-like IPR021177 Serum albumin/Alpha-fetoprotein |
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| PFAM |
PF00273
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| PRINTS |
PR00802
PR00803 |
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| PIRSF |
PIRSF002520
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| SMART |
SM00103
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | P43652 | ||||||||
| PhosphoSite | PhosphoSite-P43652 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 173 | ||||||||
| UniGene | Hs.168718 | ||||||||
| RefSeq | NP_001124 | ||||||||
| HUGO | HGNC:316 | ||||||||
| OMIM | 104145 | ||||||||
| CCDS | CCDS3557 | ||||||||
| HPRD | 00073 | ||||||||
| IMGT | |||||||||
| EMBL | AC108157 AC110752 AK290556 BC109020 BC109021 CH471057 L32140 L35486 L35497 L35498 U51243 | ||||||||
| GenPept | AAA21612 AAA68197 AAA68198 AAA68199 AAC50720 AAI09021 AAI09022 AAY41051 BAF83245 EAX05682 | ||||||||