InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLF10

Summary

InnateDB Protein

IDBP-238657.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLF10

Protein Name

Kruppel-like factor 10

Synonyms

EGR-alpha; EGRA; TIEG; TIEG1;

Species

Homo sapiens

Ensembl Protein

ENSP00000379222

InnateDB Gene

IDBG-31363 (KLF10)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5'-GGTGTG-3'. {ECO:0000269PubMed:8584037}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	27 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0006351	transcription, DNA-templated
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0008283	cell proliferation
GO:0008285	negative regulation of cell proliferation