Version 5.4
Homo sapiens Protein: CAST
Summary
InnateDB Protein IDBP-238675.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAST
Protein Name calpastatin
Synonyms BS-17;
Species Homo sapiens
Ensembl Protein ENSP00000379158
InnateDB Gene IDBG-34327 (CAST)
Protein Structure
UniProt Annotation
Function Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:2000675 negative regulation of type B pancreatic cell apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001259 Proteinase inhibitor I27, calpastatin
PFAM PF00748
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P20810
PhosphoSite PhosphoSite-P20810
TrEMBL Q13940
UniProt Splice Variant
Entrez Gene 831
UniGene Hs.738388
RefSeq XP_006714759
HUGO HGNC:1515
OMIM 114090
CCDS
HPRD 00233
IMGT
EMBL AC008906 AC020900 AC104125 AF095891 AF327443 AH002724 AK298541 AK299402 AL832349 BC013579 BC016066 BT009783 CH471084 D16217 D50827 M28227 M28228 M28229 M28230 M33328 M86258 S73329 U26724 U31345 U31346 U38525
GenPept AAA52066 AAA52296 AAA52759 AAA80684 AAB32311 AAB59398 AAB60371 AAB60372 AAC50136 AAD09102 AAG48151 AAH13579 AAH16066 AAP88785 BAA03747 BAA09438 BAH12810 BAH13025 EAW96068 EAW96071 EAW96075

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca