InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP6V1C1

Summary

InnateDB Protein

IDBP-238709.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V1C1

Protein Name

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1

Synonyms

ATP6C; ATP6D; VATC; Vma5;

Species

Homo sapiens

Ensembl Protein

ENSP00000379203

InnateDB Gene

IDBG-31515 (ATP6V1C1)

Protein Structure

UniProt Annotation

Function

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:12384298}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	44 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0046961	proton-transporting ATPase activity, rotational mechanism

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0008286	insulin receptor signaling pathway
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0033572	transferrin transport
GO:0051701	interaction with host
GO:0055085	transmembrane transport
GO:0090382	phagosome maturation

Cellular Component

GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016469	proton-transporting two-sector ATPase complex
GO:0031410	cytoplasmic vesicle
GO:0033180	proton-transporting V-type ATPase, V1 domain
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome