Version 5.4
Homo sapiens Protein: METTL21D
Summary
InnateDB Protein IDBP-238713.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol METTL21D
Protein Name methyltransferase like 21D
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000379200
InnateDB Gene IDBG-5888 (METTL21D)
Protein Structure
UniProt Annotation
Function Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity. {ECO:0000269PubMed:22948820, ECO:0000269PubMed:23349634}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:23349634}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016279 protein-lysine N-methyltransferase activity
Biological Process
GO:0018023 peptidyl-lysine trimethylation
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR019410 Nicotinamide N-methyltransferase-like
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF10294
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H867
PhosphoSite PhosphoSite-Q9H867
TrEMBL
UniProt Splice Variant
Entrez Gene 79609
UniGene Hs.700930
RefSeq NP_001035752
HUGO HGNC:20352
OMIM 615260
CCDS CCDS41951
HPRD 16605
IMGT
EMBL AK023982 AK129564 AL109758 BC027585 BC105118 BC143673 BC143674 BX247997
GenPept AAI05119 AAI43674 AAI43675 BAB14752 BAC85183 CAD62329

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca