InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APIP

Summary

InnateDB Protein

IDBP-238844.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APIP

Protein Name

APAF1 interacting protein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000379133

InnateDB Gene

IDBG-39476 (APIP)

Protein Structure

UniProt Annotation

Function

Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. {ECO:0000255HAMAP-Rule:MF_03116, ECO:0000269PubMed:15262985, ECO:0000269PubMed:22837397, ECO:0000269PubMed:23285211}.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03116, ECO:0000269PubMed:15262985, ECO:0000269PubMed:23285211}.

Disease Associations

Tissue Specificity

Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney. {ECO:0000269PubMed:15262985, ECO:0000269PubMed:23285211}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	13 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042802	identical protein binding
GO:0046570	methylthioribulose 1-phosphate dehydratase activity
GO:0046872	metal ion binding

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0006595	polyamine metabolic process
GO:0006915	apoptotic process
GO:0019284	L-methionine biosynthetic process from S-adenosylmethionine
GO:0019509	L-methionine biosynthetic process from methylthioadenosine
GO:0034641	cellular nitrogen compound metabolic process
GO:0043066	negative regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0070372	regulation of ERK1 and ERK2 cascade