Version 5.4
Homo sapiens Protein: EBAG9
Summary
InnateDB Protein IDBP-238849.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EBAG9
Protein Name estrogen receptor binding site associated, antigen, 9
Synonyms EB9; PDAF;
Species Homo sapiens
Ensembl Protein ENSP00000379131
InnateDB Gene IDBG-32695 (EBAG9)
Protein Structure
UniProt Annotation
Function May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting enzyme (ICE)-like proteases. {ECO:0000269PubMed:12054692, ECO:0000269PubMed:12138241, ECO:0000269PubMed:12672804}.
Subcellular Localization Golgi apparatus membrane {ECO:0000269PubMed:12672804}; Single-pass type III membrane protein {ECO:0000269PubMed:12672804}. Note=According to PubMed:10426319, it also exists as a soluble form which has the same biological activities. The existence of such soluble form is however uncertain.
Disease Associations
Tissue Specificity Widely expressed. Expressed in ovary, testis, prostate, thymus, muscle and heart, but not in small intestine, colon, lymph nodes, or peripherical blood lymphocytes. The protein is not detected in any of the above organs.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 3 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016505 peptidase activator activity involved in apoptotic process
Biological Process
GO:0001558 regulation of cell growth
GO:0006915 apoptotic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR017025 Cancer-associated antigen RCAS1
PFAM
PRINTS
PIRSF PIRSF034247
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00559
PhosphoSite PhosphoSite-O00559
TrEMBL Q6R3F1
UniProt Splice Variant
Entrez Gene 9166
UniGene Hs.632960
RefSeq NP_936056
HUGO HGNC:3123
OMIM 605772
CCDS CCDS6313
HPRD 05775
IMGT
EMBL AB007619 AC079061 AF006265 AP000427 AY515724 BC005249 BC017729 BC022506 CH471060 CR456984
GenPept AAB61617 AAH05249 AAH17729 AAH22506 AAR97974 BAA22572 CAG33265 EAW91932 EAW91933

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca