InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CXCL1

Summary

InnateDB Protein

IDBP-238912.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCL1

Protein Name

chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

Synonyms

FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3; SCYB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000379110

InnateDB Gene

IDBG-24070 (CXCL1)

Protein Structure

UniProt Annotation

Function

Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. {ECO:0000269PubMed:10095777}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	15 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0008009	chemokine activity
GO:0008047	enzyme activator activity
GO:0008083	growth factor activity

Biological Process

GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007399	nervous system development
GO:0008283	cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0030036	actin cytoskeleton organization
GO:0035556	intracellular signal transduction
GO:0043085	positive regulation of catalytic activity
GO:0060326	cell chemotaxis