InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SULT1A2

Summary

InnateDB Protein

IDBP-239180.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SULT1A2

Protein Name

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2

Synonyms

HAST4; P-PST; ST1A2; STP2; TSPST2;

Species

Homo sapiens

Ensembl Protein

ENSP00000378992

InnateDB Gene

IDBG-22934 (SULT1A2)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004062	aryl sulfotransferase activity
GO:0008146	sulfotransferase activity
GO:0047894	flavonol 3-sulfotransferase activity

Biological Process

GO:0006584	catecholamine metabolic process
GO:0006805	xenobiotic metabolic process
GO:0008152	metabolic process
GO:0008202	steroid metabolic process
GO:0009309	amine biosynthetic process
GO:0018958	phenol-containing compound metabolic process
GO:0044281	small molecule metabolic process
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0051923	sulfation