Version 5.4
Homo sapiens Protein: SLC47A1
Summary
InnateDB Protein IDBP-239249.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC47A1
Protein Name solute carrier family 47, member 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000378951
InnateDB Gene IDBG-34817 (SLC47A1)
Protein Structure
UniProt Annotation
Function Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes. {ECO:0000269PubMed:16330770, ECO:0000269PubMed:16996621, ECO:0000269PubMed:17495125, ECO:0000269PubMed:17509534, ECO:0000269PubMed:17582384}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:16330770, ECO:0000269PubMed:16641166}; Multi-pass membrane protein {ECO:0000269PubMed:16330770, ECO:0000269PubMed:16641166}. Note=Predominantly localized at the plasma membrane but also found in intracellular organelles.
Disease Associations
Tissue Specificity Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney (especially found in luminal membranes of the urinary tubules, bile caniculi and brush border membranes). {ECO:0000269PubMed:16330770, ECO:0000269PubMed:17509534}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015238 drug transmembrane transporter activity
GO:0015297 antiporter activity
Biological Process
GO:0006855 drug transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002528 Multi antimicrobial extrusion protein
PFAM PF01554
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96FL8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 55244
UniGene Hs.603255
RefSeq
HUGO HGNC:25588
OMIM 609832
CCDS
HPRD 07703
IMGT
EMBL AK001709 AK222625 BC010661 BC050592 BC058882 CH471212
GenPept AAH10661 AAH50592 AAH58882 BAA91852 BAD96345 EAW50893 EAW50894

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca