Version 5.4
Homo sapiens Protein: PPHLN1
Summary
InnateDB Protein IDBP-239257.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPHLN1
Protein Name periphilin 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000378935
InnateDB Gene IDBG-27733 (PPHLN1)
Protein Structure
UniProt Annotation
Function Involved in epithelial differentiation and contributes to epidermal integrity and barrier formation.
Subcellular Localization Nucleus {ECO:0000269PubMed:12853457}. Cytoplasm {ECO:0000269PubMed:12853457}. Note=In undifferentiated keratinocytes expressed in speckle-type nuclear granules and at the nuclear membrane, but in the differentiated keratinocytes colocalized with periplakin at the cell periphery and at cell-cell junctions.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:12853457}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
Biological Process
GO:0031424 keratinization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NEY8
PhosphoSite PhosphoSite-Q8NEY8
TrEMBL F8VWU8
UniProt Splice Variant
Entrez Gene 51535
UniGene Hs.635855
RefSeq NP_057572
HUGO HGNC:19369
OMIM 608150
CCDS CCDS31777
HPRD 10488
IMGT
EMBL AC020629 AC079601 AC079684 AF151040 AF151066 AK000186 AK055690 AY039238 AY157850 BC025306 BC039832 CR621833
GenPept AAF36126 AAF36152 AAH25306 AAH39832 AAK68657 AAO16497 BAA90996 BAB70985

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca