InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASAH2

Summary

InnateDB Protein

IDBP-239370.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASAH2

Protein Name

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000378897

InnateDB Gene

IDBG-74349 (ASAH2)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract. {ECO:0000269PubMed:15946935, ECO:0000269PubMed:16061940}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15845354}; Single-pass type II membrane protein {ECO:0000269PubMed:15845354}. Note=The neutral ceramidase soluble form is a secreted protein. According to PubMed:10781606, it is mitochondrial. However, they used a shorter form in its N- terminus, which may explain this localization which probably does not exist in vivo.

Disease Associations

Tissue Specificity

Primarily expressed in the intestine (PubMed:17334805). Ubiquitously expressed with higher levels in kidney, skeletal muscle and heart (PubMed:10781606). According to PubMed:17334805, ubiquitous expression attributed to ASAH2 may be actually that of the paralog ASAH2B. {ECO:0000269PubMed:10781606, ECO:0000269PubMed:17334805}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0017040	ceramidase activity

Biological Process

GO:0006665	sphingolipid metabolic process
GO:0006672	ceramide metabolic process
GO:0006687	glycosphingolipid metabolic process
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0044281	small molecule metabolic process