InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP2A1

Summary

InnateDB Protein

IDBP-239385.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP2A1

Protein Name

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

Synonyms

ATP2A; SERCA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000378879

InnateDB Gene

IDBG-23611 (ATP2A1)

Protein Structure

UniProt Annotation

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Brody myopathy (BRM) [MIM:601003]: A disorder of muscle function that is characterized by painless muscle cramping and exercise-induced impairment of muscle relaxation. {ECO:0000269PubMed:10914677}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Skeletal muscle, fast twitch muscle (type II) fibers.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005388	calcium-transporting ATPase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019829	cation-transporting ATPase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0006942	regulation of striated muscle contraction
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0008637	apoptotic mitochondrial changes
GO:0031448	positive regulation of fast-twitch skeletal muscle fiber contraction
GO:0032470	positive regulation of endoplasmic reticulum calcium ion concentration
GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration
GO:0034220	ion transmembrane transport
GO:0034976	response to endoplasmic reticulum stress
GO:0045988	negative regulation of striated muscle contraction
GO:0051561	positive regulation of mitochondrial calcium ion concentration
GO:0051659	maintenance of mitochondrion location
GO:0055085	transmembrane transport
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070509	calcium ion import
GO:0070588	calcium ion transmembrane transport
GO:0090076	relaxation of skeletal muscle

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum
GO:0031095	platelet dense tubular network membrane
GO:0031673	H zone
GO:0031674	I band
GO:0033017	sarcoplasmic reticulum membrane
GO:0034704	calcium channel complex
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR004014 Cation-transporting P-type ATPase, N-terminal
IPR005782 Calcium-transporting P-type ATPase, subfamily IIA, SERCA-type
IPR006068 Cation-transporting P-type ATPase, C-terminal
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM

PF00690
PF00689
PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120

PIRSF

SMART

SM00831

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt