InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DIDO1

Summary

InnateDB Protein

IDBP-239749.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DIDO1

Protein Name

death inducer-obliterator 1

Synonyms

BYE1; C20orf158; DATF-1; DATF1; DIDO2; DIDO3; DIO-1; DIO1; dJ885L7.8;

Species

Homo sapiens

Ensembl Protein

ENSP00000378749

InnateDB Gene

IDBG-85596 (DIDO1)

Protein Structure

UniProt Annotation

Function

Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269PubMed:16127461}.Isoform 2: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269PubMed:16127461}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00651}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:23831028}. Note=Translocates to the nucleus after pro-apoptotic stimuli (By similarity). Translocates to the mitotic spindle upon loss of interaction with H3K4me3 during early mitosis. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	35 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351

transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005819	spindle

Protein Structure and Domains

PDB ID

InterPro

IPR001965 Zinc finger, PHD-type
IPR003618 Transcription elongation factor S-II, central domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR012921 Spen paralogue and orthologue SPOC, C-terminal
IPR017890 Transcription elongation factor S-IIM
IPR019787 Zinc finger, PHD-finger

PFAM

PF07500
PF07744
PF00628

PRINTS

PIRSF

SMART

SM00249
SM00510

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BTC0