InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AK4

Summary

InnateDB Protein

IDBP-239777.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AK4

Protein Name

adenylate kinase 4

Synonyms

AK 4; AK3; AK3L1; AK3L2;

Species

Homo sapiens

Ensembl Protein

ENSP00000378743

InnateDB Gene

IDBG-99453 (AK4)

Protein Structure

UniProt Annotation

Function

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000255HAMAP-Rule:MF_03170, ECO:0000269PubMed:19073142, ECO:0000269PubMed:19766732, ECO:0000269PubMed:23416111}.

Subcellular Localization

Mitochondrion matrix {ECO:0000255HAMAP- Rule:MF_03170, ECO:0000269PubMed:11485571, ECO:0000269PubMed:19766732}.

Disease Associations

Tissue Specificity

Highly expressed in kidney, moderately expressed in heart and liver and weakly expressed in brain. {ECO:0000269PubMed:11485571}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004017	adenylate kinase activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016776	phosphotransferase activity, phosphate group as acceptor
GO:0046899	nucleoside triphosphate adenylate kinase activity

Biological Process

GO:0001889	liver development
GO:0006165	nucleoside diphosphate phosphorylation
GO:0006172	ADP biosynthetic process
GO:0007420	brain development
GO:0009142	nucleoside triphosphate biosynthetic process
GO:0042493	response to drug
GO:0046033	AMP metabolic process
GO:0046034	ATP metabolic process
GO:0046039	GTP metabolic process
GO:0046939	nucleotide phosphorylation

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000850 Adenylate kinase/UMP-CMP kinase
IPR006259 Adenylate kinase subfamily
IPR007862 Adenylate kinase, active site lid domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF05191

PRINTS

PR00094

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P27144