InnateDB Protein
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IDBP-239799.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CRCP
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Protein Name
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CGRP receptor component
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000378736
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InnateDB Gene
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IDBG-408285 (CRCP)
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Protein Structure
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Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa- B through the RIG-I pathway (By similarity). {ECO:0000250}.Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Most prevalent in testis. {ECO:0000269PubMed:10067875}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005574
RNA polymerase II, Rpb4
IPR006590
RNA polymerase II, Rpb4, core
IPR010997
HRDC-like
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PFAM |
PF03874
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PRINTS |
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PIRSF |
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SMART |
SM00657
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TIGRFAMs |
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Modification |
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SwissProt |
O75575
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PhosphoSite |
PhosphoSite-O75575
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TrEMBL |
A0A024RDL0
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UniProt Splice Variant |
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Entrez Gene |
27297
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UniGene |
Hs.614322
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RefSeq |
NP_055293
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HUGO |
HGNC:17888
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OMIM |
606121
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CCDS |
CCDS5532
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HPRD |
12089
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IMGT |
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EMBL |
AC068533
AF073792
AK290553
AK303737
AK311829
BC040107
BC105808
BP233211
BX647867
CH471140
U51134
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GenPept |
AAC25992
AAD05036
AAH40107
AAI05809
BAF83242
BAG34771
BAG64710
CAI46069
EAX07941
EAX07943
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