InnateDB Protein
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IDBP-239996.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AGPAT9
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Protein Name
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1-acylglycerol-3-phosphate O-acyltransferase 9
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000378651
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InnateDB Gene
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IDBG-27850 (AGPAT9)
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Protein Structure
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Function |
May transfer the acyl-group from acyl-coA to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Also transfers the acyl-group from acyl-coA to the sn-2 position of 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, or LPA), forming 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid, or PA). {ECO:0000269PubMed:17002884, ECO:0000269PubMed:17170135, ECO:0000269PubMed:19318427}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:17002884, ECO:0000269PubMed:19318427}; Multi- pass membrane protein {ECO:0000269PubMed:17002884, ECO:0000269PubMed:19318427}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Expressed in liver, kidney, testis, brain, heart, skeletal muscle, thyroid, prostate, thymus and placenta. Also expressed lung and adipose tissue. {ECO:0000269PubMed:17002884, ECO:0000269PubMed:17170135}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0003841
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1-acylglycerol-3-phosphate O-acyltransferase activity
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GO:0004366
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glycerol-3-phosphate O-acyltransferase activity
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GO:0016746
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transferase activity, transferring acyl groups
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002123
Phospholipid/glycerol acyltransferase
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PFAM |
PF01553
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PRINTS |
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PIRSF |
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SMART |
SM00563
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TIGRFAMs |
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Modification |
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SwissProt |
Q53EU6
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PhosphoSite |
PhosphoSite-Q53EU6
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TrEMBL |
A0A024RDG5
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UniProt Splice Variant |
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Entrez Gene |
84803
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UniGene |
Hs.99196
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RefSeq |
NP_001243350
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HUGO |
HGNC:28157
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OMIM |
610958
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CCDS |
CCDS3606
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HPRD |
14417
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IMGT |
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EMBL |
AB075872
AK055749
AK223543
AY358100
BC073136
BC090956
CH471057
DQ324782
DQ345298
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GenPept |
AAH73136
AAH90956
AAQ88467
ABC55674
ABC70186
BAB71002
BAD38654
BAD97263
EAX05945
EAX05946
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