InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MATK

Summary

InnateDB Protein

IDBP-240322.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MATK

Protein Name

megakaryocyte-associated tyrosine kinase

Synonyms

CHK; CTK; HHYLTK; HYL; HYLTK; Lsk;

Species

Homo sapiens

Ensembl Protein

ENSP00000378485

InnateDB Gene

IDBG-17829 (MATK)

Protein Structure

UniProt Annotation

Function

Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation. {ECO:0000269PubMed:9171348}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:9171348}. Membrane {ECO:0000269PubMed:9171348}. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.

Disease Associations

Tissue Specificity

Expressed in various myeloid cell lines, detected in brain and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007498	mesoderm development
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0018108	peptidyl-tyrosine phosphorylation

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00017
PF14633
PF07714
PF00018
PF14604

PRINTS

PR00401
PR00109
PR00452

PIRSF

SMART

SM00252
SM00326
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt