InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP1A1

Summary

InnateDB Protein

IDBP-240351.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP1A1

Protein Name

cytochrome P450, family 1, subfamily A, polypeptide 1

Synonyms

AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX;

Species

Homo sapiens

Ensembl Protein

ENSP00000378488

InnateDB Gene

IDBG-22475 (CYP1A1)

Protein Structure

UniProt Annotation

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Lung, lymphocytes and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0019825	oxygen binding
GO:0020037	heme binding
GO:0070330	aromatase activity
GO:0070576	vitamin D 24-hydroxylase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0017144	drug metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019373	epoxygenase P450 pathway
GO:0042359	vitamin D metabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0071407	cellular response to organic cyclic compound
GO:0097267	omega-hydroxylase P450 pathway

Cellular Component

GO:0005789

endoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
IPR008066 Cytochrome P450, E-class, group I, CYP1

PFAM

PF00067

PRINTS

PR00385
PR00463
PR00465
PR01683

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P04798