InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TCF7

Summary

InnateDB Protein

IDBP-240367.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TCF7

Protein Name

transcription factor 7 (T-cell specific, HMG-box)

Synonyms

TCF-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000378469

InnateDB Gene

IDBG-44412 (TCF7)

Protein Structure

UniProt Annotation

Function

Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T- lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium. {ECO:0000269PubMed:10489374}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	7 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006955	immune response
GO:0007420	brain development
GO:0048699	generation of neurons
GO:0060070	canonical Wnt signaling pathway
GO:0071353	cellular response to interleukin-4