InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PHF15

Summary

InnateDB Protein

IDBP-240438.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHF15

Protein Name

PHD finger protein 15

Synonyms

JADE-2; PHF15;

Species

Homo sapiens

Ensembl Protein

ENSP00000378451

InnateDB Gene

IDBG-44914 (PHF15)

Protein Structure

UniProt Annotation

Function

Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. {ECO:0000269PubMed:16387653}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0043966	histone H3 acetylation
GO:0043981	histone H4-K5 acetylation
GO:0043982	histone H4-K8 acetylation
GO:0043983	histone H4-K12 acetylation

Cellular Component

GO:0000123	histone acetyltransferase complex
GO:0005634	nucleus
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001965 Zinc finger, PHD-type
IPR011011 Zinc finger, FYVE/PHD-type
IPR019542 Enhancer of polycomb-like, N-terminal
IPR019787 Zinc finger, PHD-finger

PFAM

PF10513
PF00628

PRINTS

PIRSF

SMART

SM00249

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NQC1