Version 5.4
Homo sapiens Protein: ZNF397
Summary
InnateDB Protein IDBP-2405.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZNF397
Protein Name zinc finger protein 397
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000261333
InnateDB Gene IDBG-2399 (ZNF397)
Protein Structure
UniProt Annotation
Function Isoform 3 acts as a DNA-dependent transcriptional repressor. {ECO:0000269PubMed:12801647}.
Subcellular Localization Isoform 1: Nucleus.Isoform 3: Nucleus. Cytoplasm.
Disease Associations
Tissue Specificity Expressed strongly in testis, moderately in skeletal muscle, pancreas and prostate, and weakly in heart, placenta, liver, kidney, spleen, thymus and small intestine. {ECO:0000269PubMed:12801647}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR003309 Transcription regulator SCAN
IPR008916 Retrovirus capsid, C-terminal
PFAM PF02023
PRINTS
PIRSF
SMART SM00431
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NF99
PhosphoSite PhosphoSite-Q8NF99
TrEMBL M0R288
UniProt Splice Variant
Entrez Gene 84307
UniGene Hs.666054
RefSeq NP_115723
HUGO HGNC:18818
OMIM 609601
CCDS CCDS32814
HPRD 18335
IMGT
EMBL AC011815 AF533250 AY157641 BC006172
GenPept AAH06172 AAM95991 AAN65175

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca