InnateDB Protein
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IDBP-240636.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NRG4
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Protein Name
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neuregulin 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000378367
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InnateDB Gene
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IDBG-23842 (NRG4)
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Protein Structure
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Function |
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity). {ECO:0000250}.
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Subcellular Localization |
Pro-neuregulin-4, membrane-bound isoform: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.Neuregulin-4: Secreted {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0007173
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epidermal growth factor receptor signaling pathway
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GO:0008543
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fibroblast growth factor receptor signaling pathway
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GO:0038095
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Fc-epsilon receptor signaling pathway
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GO:0045087
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innate immune response
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GO:0048011
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neurotrophin TRK receptor signaling pathway
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GO:0048015
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phosphatidylinositol-mediated signaling
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Cellular Component |
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PDB ID |
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InterPro |
IPR000742
Epidermal growth factor-like domain
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PFAM |
PF00008
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PRINTS |
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PIRSF |
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SMART |
SM00181
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TIGRFAMs |
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Modification |
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SwissProt |
Q8WWG1
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q68D87
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UniProt Splice Variant |
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Entrez Gene |
145957
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UniGene |
Hs.739542
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RefSeq |
NP_612640
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HUGO |
HGNC:29862
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OMIM |
610894
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CCDS |
CCDS10288
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HPRD |
14871
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IMGT |
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EMBL |
AC027104
AC087456
AC091100
BC017568
CH471136
CR749519
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GenPept |
AAH17568
CAH18333
EAW99227
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