InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIF20A

Summary

InnateDB Protein

IDBP-240648.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIF20A

Protein Name

kinesin family member 20A

Synonyms

MKLP2; RAB6KIFL;

Species

Homo sapiens

Ensembl Protein

ENSP00000378356

InnateDB Gene

IDBG-46715 (KIF20A)

Protein Structure

UniProt Annotation

Function

Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269PubMed:12939256}.

Subcellular Localization

Golgi apparatus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:12939256}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	13 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005215	transporter activity
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0019901	protein kinase binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0000910	cytokinesis
GO:0001578	microtubule bundle formation
GO:0007018	microtubule-based movement
GO:0008152	metabolic process
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport