InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TIMM44

Summary

InnateDB Protein

IDBP-24069.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIMM44

Protein Name

translocase of inner mitochondrial membrane 44 homolog (yeast)

Synonyms

TIM44;

Species

Homo sapiens

Ensembl Protein

ENSP00000270538

InnateDB Gene

IDBG-24067 (TIMM44)

Protein Structure

UniProt Annotation

Function

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source.

Subcellular Localization

Mitochondrion inner membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.

Experimentally validated
Total	30 [view]
Protein-Protein	27 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity

Biological Process

GO:0006626	protein targeting to mitochondrion
GO:0006886	intracellular protein transport
GO:0044267	cellular protein metabolic process
GO:0071806	protein transmembrane transport