InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GIT1

Summary

InnateDB Protein

IDBP-240701.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GIT1

Protein Name

G protein-coupled receptor kinase interacting ArfGAP 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000378338

InnateDB Gene

IDBG-38394 (GIT1)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes. {ECO:0000269PubMed:11896197}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11896197}. Note=Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytoplasmic complexes and membrane protrusions. During cell migration, when cells detach, moves from the adhesions into the cytoplasmic complexes towards the leading edge, while, when cells adhere, it is found in vinculin-containing adhesions. Recruitment to adhesions may be mediated by active tyrosine-phosphorylated paxillin.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	82 [view]
Protein-Protein	82 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding

Biological Process

GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0032312	regulation of ARF GTPase activity
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005737	cytoplasm
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0016235	aggresome

Protein Structure and Domains

PDB ID

InterPro

IPR001164 Arf GTPase activating protein
IPR002110 Ankyrin repeat
IPR013724 Spa2 homology (SHD) of GIT
IPR020683 Ankyrin repeat-containing domain
IPR022018 G protein-coupled receptor kinase-interacting protein 1 C term

PFAM