InnateDB Protein
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IDBP-240725.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TGFB1I1
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Protein Name
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transforming growth factor beta 1 induced transcript 1
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Synonyms
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ARA55; HIC-5; HIC5; TSC-5;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000378327
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InnateDB Gene
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IDBG-28530 (TGFB1I1)
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Protein Structure
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Function |
Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA- binding activity. {ECO:0000269PubMed:10075738, ECO:0000269PubMed:11463817, ECO:0000269PubMed:11856738, ECO:0000269PubMed:12177201, ECO:0000269PubMed:12445807, ECO:0000269PubMed:12700349, ECO:0000269PubMed:15211577, ECO:0000269PubMed:15561701, ECO:0000269PubMed:16141357, ECO:0000269PubMed:16624805, ECO:0000269PubMed:16803896, ECO:0000269PubMed:16849583, ECO:0000269PubMed:17166536, ECO:0000269PubMed:17233630, ECO:0000269PubMed:9032249}.
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Subcellular Localization |
Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton; colocalizes with stress fibers.
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Disease Associations |
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Tissue Specificity |
Expressed in platelets, smooth muscle and prostate stromal cells (at protein level). {ECO:0000269PubMed:10075738, ECO:0000269PubMed:10708479, ECO:0000269PubMed:11311131, ECO:0000269PubMed:12642630, ECO:0000269PubMed:12772188, ECO:0000269PubMed:16849583, ECO:0000269PubMed:17166536, ECO:0000269PubMed:17233630, ECO:0000269PubMed:9664039}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
43
[view]
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Protein-Protein |
43
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
GO:0006366
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transcription from RNA polymerase II promoter
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GO:0007155
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cell adhesion
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GO:0008285
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negative regulation of cell proliferation
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GO:0010718
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positive regulation of epithelial to mesenchymal transition
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GO:0016055
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Wnt signaling pathway
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GO:0030511
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positive regulation of transforming growth factor beta receptor signaling pathway
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GO:0030512
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negative regulation of transforming growth factor beta receptor signaling pathway
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GO:0030521
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androgen receptor signaling pathway
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GO:0030579
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ubiquitin-dependent SMAD protein catabolic process
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GO:0045893
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positive regulation of transcription, DNA-templated
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Cellular Component |
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PDB ID |
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InterPro |
IPR001781
Zinc finger, LIM-type
IPR017305
Transforming growth factor beta-1-induced transcript 1 protein/Leupaxin
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PFAM |
PF00412
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PRINTS |
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PIRSF |
PIRSF037881
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SMART |
SM00132
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TIGRFAMs |
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Modification |
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SwissProt |
O43294
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PhosphoSite |
PhosphoSite-O43294
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TrEMBL |
H3BSN4
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UniProt Splice Variant |
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Entrez Gene |
7041
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UniGene |
Hs.605421
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RefSeq |
NP_057011
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HUGO |
HGNC:11767
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OMIM |
602353
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CCDS |
CCDS10713
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HPRD |
03831
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IMGT |
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EMBL |
AB007836
AC026471
AF116343
AK313327
BC001507
BC001830
BC017288
BC032545
CH471192
DQ309025
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GenPept |
AAD22552
AAH01507
AAH01830
AAH17288
AAH32545
ABB96286
BAA24799
BAG36132
EAW52126
EAW52128
EAW52130
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