Version 5.4
Homo sapiens Protein: UPK3B
Summary
InnateDB Protein IDBP-240761.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UPK3B
Protein Name uroplakin 3B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000378319
InnateDB Gene IDBG-409323 (UPK3B)
Protein Structure
UniProt Annotation
Function Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER). {ECO:0000269PubMed:12446744}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0010629 negative regulation of gene expression
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BT76
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 80761
UniGene Hs.488861
RefSeq NP_872624
HUGO HGNC:21444
OMIM 611887
CCDS CCDS64693
HPRD 15626
IMGT
EMBL AC004980 AC006972 AC007003 AC007078 AC114737 AK056760 AK290096 AY233462 BC004304
GenPept AAH04304 AAO89507 AAS07526 BAF82785 BAG51807

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca