Version 5.4
Homo sapiens Protein: SLC39A8
Summary
InnateDB Protein IDBP-240791.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC39A8
Protein Name solute carrier family 39 (zinc transporter), member 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000378310
InnateDB Gene IDBG-31944 (SLC39A8)
Protein Structure
UniProt Annotation
Function Acts as a zinc-influx transporter. {ECO:0000269PubMed:12504855}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Associated with the lysosomal/endosomal compartment following transfection. {ECO:0000269PubMed:12504855}.
Disease Associations
Tissue Specificity Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas. {ECO:0000269PubMed:12504855}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 0
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006829 zinc ion transport
GO:0030001 metal ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031090 organelle membrane
Protein Structure and Domains
PDB ID
InterPro IPR003689 Zinc/iron permease
PFAM PF02535
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9C0K1
PhosphoSite PhosphoSite-Q9C0K1
TrEMBL A0A024RDG0
UniProt Splice Variant
Entrez Gene 64116
UniGene Hs.288034
RefSeq NP_071437
HUGO HGNC:20862
OMIM 608732
CCDS CCDS3656
HPRD 12286
IMGT
EMBL AB020970 AB040120 AC098487 AF193052 AK027652 AK304274 AP002023 BC001320 BC012125 CH471057
GenPept AAG22480 AAH01320 AAH12125 BAA96442 BAB21559 BAB55268 BAG65135 EAX06130 EAX06131 EAX06132

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca