InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BHLHE41

Summary

InnateDB Protein

IDBP-24080.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BHLHE41

Protein Name

basic helix-loop-helix family, member e41

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000242728

InnateDB Gene

IDBG-24078 (BHLHE41)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. {ECO:0000269PubMed:11278948, ECO:0000269PubMed:14672706, ECO:0000269PubMed:15193144, ECO:0000269PubMed:15560782, ECO:0000269PubMed:18411297, ECO:0000269PubMed:19786558}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00380, ECO:0000255PROSITE-ProRule:PRU00981}.

Disease Associations

Tissue Specificity

Highly expressed in skeletal muscle and brain, moderately expressed in pancreas and heart, weakly expressed in placenta, lung, liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001191	RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0043425	bHLH transcription factor binding
GO:0043426	MRF binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007623	circadian rhythm
GO:0008283	cell proliferation
GO:0009887	organ morphogenesis
GO:0010832	negative regulation of myotube differentiation
GO:0010944	negative regulation of transcription by competitive promoter binding
GO:0030154	cell differentiation
GO:0032922	circadian regulation of gene expression
GO:0045892	negative regulation of transcription, DNA-templated