InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAB11FIP4

Summary

InnateDB Protein

IDBP-240962.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAB11FIP4

Protein Name

RAB11 family interacting protein 4 (class II)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000378227

InnateDB Gene

IDBG-39682 (RAB11FIP4)

Protein Structure

UniProt Annotation

Function

Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. {ECO:0000269PubMed:12470645}.

Subcellular Localization

Recycling endosome membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Cytoplasmic vesicle. Note=Recruited to the cleavage furrow and the midbody during cytokinesis.

Disease Associations

Tissue Specificity

Present at high level in testis (at protein level). Weakly expressed in other tissues. {ECO:0000269PubMed:12857874}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0017137	Rab GTPase binding
GO:0030306	ADP-ribosylation factor binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000910	cytokinesis
GO:0006810	transport
GO:0016032	viral process

Cellular Component

GO:0005615	extracellular space
GO:0005768	endosome
GO:0030139	endocytic vesicle
GO:0030496	midbody
GO:0032154	cleavage furrow
GO:0055038	recycling endosome membrane