InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PF4

Summary

InnateDB Protein

IDBP-24099.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PF4

Protein Name

platelet factor 4

Synonyms

CXCL4; PF-4; SCYB4;

Species

Homo sapiens

Ensembl Protein

ENSP00000296029

InnateDB Gene

IDBG-24097 (PF4)

Protein Structure

UniProt Annotation

Function

Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. {ECO:0000269PubMed:7644496}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity
GO:0008201	heparin binding
GO:0048248	CXCR3 chemokine receptor binding

Biological Process

GO:0002576	platelet degranulation
GO:0006955	immune response
GO:0007596	blood coagulation
GO:0010628	positive regulation of gene expression
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0016525	negative regulation of angiogenesis
GO:0019221	cytokine-mediated signaling pathway
GO:0030168	platelet activation
GO:0030595	leukocyte chemotaxis
GO:0030816	positive regulation of cAMP metabolic process
GO:0032760	positive regulation of tumor necrosis factor production
GO:0042127	regulation of cell proliferation
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0045347	negative regulation of MHC class II biosynthetic process
GO:0045651	positive regulation of macrophage differentiation
GO:0045653	negative regulation of megakaryocyte differentiation
GO:0045918	negative regulation of cytolysis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand