InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CFI

Summary

InnateDB Protein

IDBP-241175.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CFI

Protein Name

complement factor I

Synonyms

AHUS3; ARMD13; C3b-INA; C3BINA; FI; IF; KAF;

Species

Homo sapiens

Ensembl Protein

ENSP00000378131

InnateDB Gene

IDBG-33966 (CFI)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005044	scavenger receptor activity
GO:0005515	protein binding

Biological Process

GO:0006508	proteolysis
GO:0006898	receptor-mediated endocytosis

Cellular Component

GO:0016020

membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001190 SRCR domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR003884 Factor I / membrane attack complex
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR017448 SRCR-like domain

PFAM

PF00530
PF00089
PF00057

PRINTS

PR00258
PR00722
PR00261

PIRSF

SMART

SM00020
SM00192
SM00057
SM00202

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt