Version 5.4
Homo sapiens Protein: TRPT1
Summary
InnateDB Protein IDBP-241362.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRPT1
Protein Name tRNA phosphotransferase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000378051
InnateDB Gene IDBG-53204 (TRPT1)
Protein Structure
UniProt Annotation
Function Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate. {ECO:0000305PubMed:14504659}.
Subcellular Localization
Disease Associations
Tissue Specificity Widely expressed. Weakly or not expressed in lung, spleen, small intestine and peripheral blood leukocytes. {ECO:0000269PubMed:14504659}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000215 tRNA 2'-phosphotransferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR002745 Phosphotransferase KptA/Tpt1
PFAM PF01885
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86TN4
PhosphoSite PhosphoSite-Q86TN4
TrEMBL A0A024R5C2
UniProt Splice Variant
Entrez Gene 83707
UniGene
RefSeq NP_113660
HUGO HGNC:20316
OMIM 610470
CCDS CCDS44639
HPRD 17479
IMGT
EMBL AP005668 AP006334 AY211494 BC005133 BQ672032 CH471076
GenPept AAH05133 AAO62941 EAW74202 EAW74203

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca