InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NTRK3

Summary

InnateDB Protein

IDBP-241464.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NTRK3

Protein Name

neurotrophic tyrosine kinase, receptor, type 3

Synonyms

gp145(trkC); TRKC;

Species

Homo sapiens

Ensembl Protein

ENSP00000377990

InnateDB Gene

IDBG-28355 (NTRK3)

Protein Structure

UniProt Annotation

Function

Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005030	neurotrophin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0043121	neurotrophin binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001933	negative regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030335	positive regulation of cell migration
GO:0032148	activation of protein kinase B activity
GO:0032856	activation of Ras GTPase activity
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0038179	neurotrophin signaling pathway
GO:0050927	positive regulation of positive chemotaxis
GO:2000251	positive regulation of actin cytoskeleton reorganization

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR000483 Cysteine-rich flanking region, C-terminal
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
IPR020446 Tyrosine-protein kinase, neurotrophic receptor, type 3
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020777 Tyrosine-protein kinase, neurotrophic receptor

PFAM

PF01462
PF01463
PF00069
PF07714
PF07679
PF00047

PRINTS

PR00109
PR01942
PR01939

PIRSF

SMART

SM00013
SM00082
SM00220
SM00409
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt