Version 5.4
Homo sapiens Protein: HEPACAM2
Summary
InnateDB Protein IDBP-241520.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HEPACAM2
Protein Name HEPACAM family member 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000377980
InnateDB Gene IDBG-26888 (HEPACAM2)
Protein Structure
UniProt Annotation
Function Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation. {ECO:0000269PubMed:22864114}.
Subcellular Localization Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=In interphase, localizes to the Golgi apparatus. Localizes to centrosomes and spindles during prophase, prometaphase, and metaphase of mitosis, and to midbodies at telophase. Translocation to mitotic centrosomes is the result of poly-ADP-ribosylation (PARsylation).
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:19358830}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0051297 centrosome organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005819 spindle
GO:0016021 integral component of membrane
GO:0030496 midbody
Protein Structure and Domains
PDB ID
InterPro IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
PFAM PF07679
PF07686
PF00047
PRINTS
PIRSF
SMART SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A8MVW5
PhosphoSite PhosphoSite-A8MVW5
TrEMBL
UniProt Splice Variant
Entrez Gene 253012
UniGene Hs.443169
RefSeq NP_001034461
HUGO HGNC:27364
OMIM 614133
CCDS CCDS43616
HPRD 14138
IMGT
EMBL AC000119 AC002453 AK096002 AK298361 AY358345 BC136300 BC136301 BC139906
GenPept AAI36301 AAI36302 AAI39907 AAQ88711 BAG53196 BAG60603

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca