Function |
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair. {ECO:0000250, ECO:0000269PubMed:11274402, ECO:0000269PubMed:11526476, ECO:0000269PubMed:12837246, ECO:0000269PubMed:12874027, ECO:0000269PubMed:14992727}.
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Disease Associations |
Familial multiple endocrine neoplasia type I (MEN1) [MIM:131100]: Autosomal dominant disorder characterized by tumors of the parathyroid glands, gastro-intestinal endocrine tissue, the anterior pituitary and other tissues. Cutaneous lesions and nervous-tissue tumors can exist. Prognosis in MEN1 patients is related to hormonal hypersecretion by tumors, such as hypergastrinemia causing severe peptic ulcer disease (Zollinger- Ellison syndrome, ZES), primary hyperparathyroidism, and acute forms of hyperinsulinemia. {ECO:0000269PubMed:10090472, ECO:0000269PubMed:10229909, ECO:0000269PubMed:10534569, ECO:0000269PubMed:10576763, ECO:0000269PubMed:10617276, ECO:0000269PubMed:10660339, ECO:0000269PubMed:10664520, ECO:0000269PubMed:10849016, ECO:0000269PubMed:10993647, ECO:0000269PubMed:11102994, ECO:0000269PubMed:11134142, ECO:0000269PubMed:11241849, ECO:0000269PubMed:12050235, ECO:0000269PubMed:12112656, ECO:0000269PubMed:12417605, ECO:0000269PubMed:12652570, ECO:0000269PubMed:12746426, ECO:0000269PubMed:12791038, ECO:0000269PubMed:14686752, ECO:0000269PubMed:14992727, ECO:0000269PubMed:15714081, ECO:0000269PubMed:15730416, ECO:0000269PubMed:17555499, ECO:0000269PubMed:9103196, ECO:0000269PubMed:9215689, ECO:0000269PubMed:9215690, ECO:0000269PubMed:9463336, ECO:0000269PubMed:9506756, ECO:0000269PubMed:9671267, ECO:0000269PubMed:9683585, ECO:0000269PubMed:9709921, ECO:0000269PubMed:9709976, ECO:0000269PubMed:9709985, ECO:0000269PubMed:9740255, ECO:0000269PubMed:9747036, ECO:0000269PubMed:9820618, ECO:0000269PubMed:9832038, ECO:0000269PubMed:9888389, ECO:0000269PubMed:9989505}. Note=The disease is caused by mutations affecting the gene represented in this entry.Familial isolated hyperparathyroidism (FIHP) [MIM:145000]: Autosomal dominant disorder characterized by hypercalcemia, elevated parathyroid hormone (PTH) levels, and uniglandular or multiglandular parathyroid tumors. {ECO:0000269PubMed:10634381, ECO:0000269PubMed:10664521, ECO:0000269PubMed:12016470, ECO:0000269PubMed:12699448, ECO:0000269PubMed:9792884, ECO:0000269PubMed:9843042, ECO:0000269PubMed:9888389}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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