InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPC3

Summary

InnateDB Protein

IDBP-241869.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPC3

Protein Name

glypican 3

Synonyms

DGSX; GTR2-2; MXR7; OCI-5; SDYS; SGB; SGBS; SGBS1;

Species

Homo sapiens

Ensembl Protein

ENSP00000377836

InnateDB Gene

IDBG-86754 (GPC3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043395	heparan sulfate proteoglycan binding
GO:0060422	peptidyl-dipeptidase inhibitor activity

Biological Process

GO:0001523	retinoid metabolic process
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001822	kidney development
GO:0005975	carbohydrate metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0006027	glycosaminoglycan catabolic process
GO:0007603	phototransduction, visible light
GO:0008285	negative regulation of cell proliferation
GO:0009653	anatomical structure morphogenesis
GO:0009887	organ morphogenesis
GO:0009948	anterior/posterior axis specification
GO:0010171	body morphogenesis
GO:0010466	negative regulation of peptidase activity
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030282	bone mineralization
GO:0030316	osteoclast differentiation
GO:0030324	lung development
GO:0030513	positive regulation of BMP signaling pathway
GO:0035116	embryonic hindlimb morphogenesis
GO:0040008	regulation of growth
GO:0044281	small molecule metabolic process
GO:0045732	positive regulation of protein catabolic process
GO:0045807	positive regulation of endocytosis
GO:0045879	negative regulation of smoothened signaling pathway
GO:0045880	positive regulation of smoothened signaling pathway
GO:0045926	negative regulation of growth
GO:0046326	positive regulation of glucose import
GO:0050680	negative regulation of epithelial cell proliferation
GO:0060976	coronary vasculature development
GO:0072111	cell proliferation involved in kidney development
GO:0072138	mesenchymal cell proliferation involved in ureteric bud development
GO:0072180	mesonephric duct morphogenesis
GO:0072203	cell proliferation involved in metanephros development
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000096	positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005764	lysosome
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0043202	lysosomal lumen
GO:0046658	anchored component of plasma membrane
GO:0070062	extracellular vesicular exosome