InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANXA4

Summary

InnateDB Protein

IDBP-241871.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANXA4

Protein Name

annexin A4

Synonyms

ANX4; HEL-S-274; PIG28; ZAP36;

Species

Homo sapiens

Ensembl Protein

ENSP00000377833

InnateDB Gene

IDBG-54978 (ANXA4)

Protein Structure

UniProt Annotation

Function

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004859	phospholipase inhibitor activity
GO:0005509	calcium ion binding
GO:0005544	calcium-dependent phospholipid binding
GO:0042802	identical protein binding
GO:0048306	calcium-dependent protein binding
GO:0051059	NF-kappaB binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0030855	epithelial cell differentiation
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0043066	negative regulation of apoptotic process
GO:0043086	negative regulation of catalytic activity
GO:0045087	innate immune response (InnateDB)
GO:0050819	negative regulation of coagulation
GO:2000483	negative regulation of interleukin-8 secretion

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0012506	vesicle membrane
GO:0031965	nuclear membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome