InnateDB Protein
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IDBP-241994.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SYNPO
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Protein Name
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synaptopodin
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000377789
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InnateDB Gene
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IDBG-53794 (SYNPO)
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Protein Structure
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Function |
Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Perikaryon {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the perikarya. Associated with dendritic spines of a subset of synapses (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in cerebral cortex. {ECO:0000269PubMed:9314539}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0032233
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positive regulation of actin filament bundle assembly
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GO:0051492
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regulation of stress fiber assembly
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N3V7
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PhosphoSite |
PhosphoSite-Q8N3V7
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TrEMBL |
Q71HJ6
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UniProt Splice Variant |
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Entrez Gene |
11346
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UniGene |
Hs.435228
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RefSeq |
NP_001159680
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HUGO |
HGNC:30672
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OMIM |
608155
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CCDS |
CCDS54937
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HPRD |
12179
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IMGT |
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EMBL |
AB028952
AF499136
AF499137
AF499138
AK127049
AK290178
AL831818
BC142683
BC146665
CH471062
Y11072
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GenPept |
AAI42684
AAI46666
AAQ07402
AAQ07403
AAQ07404
BAA82981
BAF82867
CAA71955
CAD38532
EAW61715
EAW61716
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