InnateDB Protein
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IDBP-242053.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DHFRL1
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Protein Name
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dihydrofolate reductase-like 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000377768
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InnateDB Gene
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IDBG-46235 (DHFRL1)
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Protein Structure
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Function |
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR. {ECO:0000269PubMed:21876184, ECO:0000269PubMed:21876188}.
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Subcellular Localization |
Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane.
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Disease Associations |
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Tissue Specificity |
Expressed in numerous cell lines. {ECO:0000269PubMed:21876184}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001796
Dihydrofolate reductase domain
IPR012259
Dihydrofolate reductase
IPR024072
Dihydrofolate reductase-like domain
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PFAM |
PF00186
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PRINTS |
PR00070
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PIRSF |
PIRSF000194
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86XF0
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PhosphoSite |
PhosphoSite-Q86XF0
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TrEMBL |
C9JJ68
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UniProt Splice Variant |
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Entrez Gene |
200895
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UniGene |
Hs.718516
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RefSeq |
NP_001182572
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HUGO |
HGNC:27309
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OMIM |
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CCDS |
CCDS2926
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HPRD |
11246
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IMGT |
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EMBL |
AC130896
AL832912
BC045541
BC063379
CH471052
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GenPept |
AAH45541
AAH63379
CAH10617
EAW79895
EAW79896
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