InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLASP2

Summary

InnateDB Protein

IDBP-24220.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLASP2

Protein Name

cytoplasmic linker associated protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000324364

InnateDB Gene

IDBG-24212 (CLASP2)

Protein Structure

UniProt Annotation

Function

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269PubMed:11290329, ECO:0000269PubMed:15631994, ECO:0000269PubMed:16824950, ECO:0000269PubMed:16866869, ECO:0000269PubMed:16914514, ECO:0000269PubMed:17543864, ECO:0000269PubMed:20937854}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cell membrane. Cell projection, ruffle membrane. Note=Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.

Disease Associations

Tissue Specificity

Brain-specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity
GO:0051010	microtubule plus-end binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007020	microtubule nucleation
GO:0007026	negative regulation of microtubule depolymerization
GO:0007067	mitotic nuclear division
GO:0007163	establishment or maintenance of cell polarity
GO:0007411	axon guidance
GO:0031023	microtubule organizing center organization
GO:0031110	regulation of microtubule polymerization or depolymerization
GO:0032886	regulation of microtubule-based process
GO:0034453	microtubule anchoring
GO:0036065	fucosylation

Cellular Component

GO:0000777	condensed chromosome kinetochore
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005815	microtubule organizing center
GO:0005828	kinetochore microtubule
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005881	cytoplasmic microtubule
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0016020	membrane
GO:0032587	ruffle membrane