Homo sapiens Protein: GAPVD1 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-242238.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | GAPVD1 | ||||||||||||||||||
Protein Name | GTPase activating protein and VPS9 domains 1 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000377664 | ||||||||||||||||||
InnateDB Gene | IDBG-85167 (GAPVD1) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. {ECO:0000269PubMed:16410077}. | ||||||||||||||||||
Subcellular Localization | Membrane {ECO:0000269PubMed:16410077}; Peripheral membrane protein {ECO:0000269PubMed:16410077}. Endosome {ECO:0000269PubMed:16410077}. Note=Recruited to the plasma membrane by TRIP10/CIP4 in response to insulin. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | |||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR001936
Ras GTPase-activating protein IPR003123 Vacuolar sorting protein 9 IPR008936 Rho GTPase activation protein IPR013995 Vacuolar sorting protein 9, subgroup |
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PFAM |
PF00616
PF02204 |
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PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART |
SM00323
SM00167 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q14C86 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q14C86 | ||||||||||||||||||
TrEMBL | C9IZX9 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 26130 | ||||||||||||||||||
UniGene | Hs.609980 | ||||||||||||||||||
RefSeq | |||||||||||||||||||
HUGO | HGNC:23375 | ||||||||||||||||||
OMIM | 611714 | ||||||||||||||||||
CCDS | CCDS65132 | ||||||||||||||||||
HPRD | 10886 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AB040954 AK000126 AL080196 AL354710 AL627223 AL834325 BC013635 BC021119 BC114937 BC114962 CH471090 DQ233254 | ||||||||||||||||||
GenPept | AAH13635 AAH21119 AAI14938 AAI14963 ABB71126 BAA90959 BAA96045 CAB45770 CAD38993 CAH71014 CAO03610 CAO03611 CAQ08735 CAQ08736 CAQ08737 EAW87622 EAW87623 | ||||||||||||||||||