InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MTHFD2

Summary

InnateDB Protein

IDBP-242373.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTHFD2

Protein Name

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

Synonyms

NMDMC;

Species

Homo sapiens

Ensembl Protein

ENSP00000377617

InnateDB Gene

IDBG-57007 (MTHFD2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004477	methenyltetrahydrofolate cyclohydrolase activity
GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0016787	hydrolase activity
GO:0042301	phosphate ion binding

Biological Process

GO:0006730	one-carbon metabolic process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0046653	tetrahydrofolate metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase
IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain

PFAM

PF00763
PF02882

PRINTS

PR00085

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P13995