InnateDB Protein
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IDBP-242418.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RALGPS1
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Protein Name
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Ral GEF with PH domain and SH3 binding motif 1
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Synonyms
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RALGEF2; RALGPS1A;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000377579
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InnateDB Gene
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IDBG-85534 (RALGPS1)
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Protein Structure
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Function |
Guanine nucleotide exchange factor (GEF) for the small GTPase RALA. May be involved in cytoskeletal organization (By similarity). Guanine nucleotide exchange factor for. {ECO:0000250, ECO:0000269PubMed:10747847, ECO:0000269PubMed:10889189}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:10889189}. Cell membrane {ECO:0000269PubMed:10889189}. Note=Associates with membranes through the PH domain.
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Disease Associations |
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Tissue Specificity |
Widely expressed (at protein level). Isoform 2 is expressed in brain, colon, kidney, pancreas, prostate, skeletal muscle, small intestine, testis, thymus and uterus. Isoform 1 is expressed at high levels in heart and testis and at lower levels in brain, pancreas, skeletal muscle, small intestine and thymus. {ECO:0000269PubMed:10747847, ECO:0000269PubMed:10889189}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005085
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guanyl-nucleotide exchange factor activity
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GO:0008321
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Ral guanyl-nucleotide exchange factor activity
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Biological Process |
GO:0007264
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small GTPase mediated signal transduction
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GO:0032485
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regulation of Ral protein signal transduction
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GO:0032852
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positive regulation of Ral GTPase activity
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GO:0035556
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intracellular signal transduction
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GO:0043547
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positive regulation of GTPase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR023578
Ras guanine nucleotide exchange factor domain
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5JS13
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PhosphoSite |
PhosphoSite-Q5JS13
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9649
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UniGene |
Hs.432842
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RefSeq |
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HUGO |
HGNC:16851
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OMIM |
614444
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CCDS |
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HPRD |
11479
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IMGT |
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EMBL |
AB002349
AF221098
AK299149
AL160169
AL356862
AL357623
AL450263
BC019329
BC032372
BC033708
CH471090
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GenPept |
AAF65253
AAH19329
AAH32372
AAH33708
BAA20808
BAG61198
CAH72699
CAH72700
CAH72701
CAH72702
CAI39718
CAI39719
CAI39720
CAI39721
CAI39723
CAI40638
CAI40639
CAI40640
CAI40641
CAI40643
CAI40644
CAI41460
CAI41461
EAW87645
EAW87646
EAW87648
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