Version 5.4
Homo sapiens Protein: ASUN
Summary
InnateDB Protein IDBP-24243.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASUN
Protein Name chromosome 12 open reading frame 11
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000261191
InnateDB Gene IDBG-24241 (ASUN)
Protein Structure
UniProt Annotation
Function Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. {ECO:0000269PubMed:15737938, ECO:0000269PubMed:23097494}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:23097494}.
Disease Associations
Tissue Specificity Widely expressed. Tends to be up-regulated in seminomas compared to normal testis. {ECO:0000269PubMed:12414650}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0007346 regulation of mitotic cell cycle
GO:0030317 sperm motility
GO:0080154 regulation of fertilization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR019355 Cell cycle regulator Mat89Bb
PFAM PF10221
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NVM9
PhosphoSite PhosphoSite-Q9NVM9
TrEMBL F8VRX9
UniProt Splice Variant
Entrez Gene 55726
UniGene Hs.596685
RefSeq NP_060634
HUGO HGNC:20174
OMIM 615079
CCDS CCDS8708
HPRD 07689
IMGT
EMBL AC024093 AK001492 AK001499 AK297948 AL137401 AY211927 BC003081 BC008368
GenPept AAH03081 AAH08368 AAO65180 BAA91721 BAA91725 BAG60263 CAB70726

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca