InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GNB2

Summary

InnateDB Protein

IDBP-242611.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNB2

Protein Name

guanine nucleotide binding protein (G protein), beta polypeptide 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000377503

InnateDB Gene

IDBG-31798 (GNB2)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000269PubMed:16498633}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.

Experimentally validated
Total	93 [view]
Protein-Protein	93 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0051020	GTPase binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006184	GTP catabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007268	synaptic transmission
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0071377	cellular response to glucagon stimulus

Cellular Component

GO:0005615	extracellular space
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001632 G-protein, beta subunit
IPR001680 WD40 repeat
IPR016346 Guanine nucleotide-binding protein, beta subunit
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat

PFAM

PF00400

PRINTS

PR00319
PR00320

PIRSF

PIRSF002394

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References