InnateDB Protein
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IDBP-242627.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PHLDB2
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Protein Name
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pleckstrin homology-like domain, family B, member 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000377500
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InnateDB Gene
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IDBG-49473 (PHLDB2)
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Protein Structure
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Function |
Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:12376540}. Membrane {ECO:0000269PubMed:12376540}; Peripheral membrane protein {ECO:0000269PubMed:12376540}. Note=Translocates to the plasma membrane at high levels of PtdIns(3,4,5)P3. At low levels of PtdIns(3,4,5)P3 is translocated to vesicular compartments.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001849
Pleckstrin homology domain
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PFAM |
PF00169
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PRINTS |
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PIRSF |
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SMART |
SM00233
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TIGRFAMs |
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Modification |
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SwissProt |
Q86SQ0
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PhosphoSite |
PhosphoSite-Q86SQ0
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TrEMBL |
Q8NEI7
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UniProt Splice Variant |
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Entrez Gene |
90102
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UniGene |
Hs.732215
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RefSeq |
NP_001127909
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HUGO |
HGNC:29573
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OMIM |
610298
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CCDS |
CCDS46885
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HPRD |
06611
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IMGT |
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EMBL |
AB209903
AC055748
AC060225
AC117509
AF506820
AJ496194
AK092996
AK096151
AL137663
BC031000
BC069194
BC142678
BC150210
CH471052
CR749654
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GenPept |
AAH31000
AAH69194
AAI42679
AAI50211
AAM33634
BAC04014
BAC04713
BAD93140
CAD42711
CAH18447
CAH56386
EAW79690
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