InnateDB Protein
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IDBP-243097.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NUMA1
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Protein Name
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nuclear mitotic apparatus protein 1
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Synonyms
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NUMA;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000377298
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InnateDB Gene
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IDBG-63041 (NUMA1)
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Protein Structure
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Function |
Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions. {ECO:0000269PubMed:19255246}.
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Subcellular Localization |
Nucleus matrix. Chromosome. Cytoplasm, cytoskeleton, spindle pole. Note=Resides in the nuclear matrix during interphases. Dissociates from condensing chromosomes during early prophase, and relocates to the spindle poles via dynein/dynamin association, it remain there until the anaphase onset. Before the complete disintegration of the nuclear lamina. As mitosis progresses it reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident.Isoform Numa-m: Cytoplasm. Note=Mainly clustered at the centrosomal region.Isoform Numa-s: Cytoplasm. Note=Mainly clustered at the centrosomal region.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
78
[view]
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Protein-Protein |
76
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
2
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR009053
Prefoldin
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q14980
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PhosphoSite |
PhosphoSite-Q14980
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TrEMBL |
Q9UPG3
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UniProt Splice Variant |
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Entrez Gene |
4926
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UniGene |
Hs.632934
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RefSeq |
NP_006176
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HUGO |
HGNC:8059
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OMIM |
164009
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CCDS |
CCDS31633
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HPRD |
01236
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IMGT |
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EMBL |
AB210007
AB621824
AF012302
AF110460
AP002490
BC004165
BC043499
CH471076
Z11583
Z11584
Z14227
Z14228
Z14229
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GenPept |
AAC33408
AAD16994
AAH04165
AAH43499
BAE06089
BAK64159
CAA77669
CAA77670
EAW74823
EAW74826
EAW74827
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