InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ETV4

Summary

InnateDB Protein

IDBP-243155.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ETV4

Protein Name

ets variant 4

Synonyms

E1A-F; E1AF; PEA3; PEAS3;

Species

Homo sapiens

Ensembl Protein

ENSP00000377273

InnateDB Gene

IDBG-52843 (ETV4)

Protein Structure

UniProt Annotation

Function

Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5'[AC]GGA[AT]GT-3'. {ECO:0000269PubMed:19307308}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0030154	cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter